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Supplement Facts

All-natural and Herbal Ingredients

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Vitamin B6 (as Pyridoxal-5-Phosphate)

  • Quantity: 30 mg
  • % Daily Value/RDI: 1500

Vitamin B6 is one of the most outstanding vitamins for overall health and wellness. It plays an essential role in the development and maintenance of a healthy immune system. Vitamin B6 is proven to provide valuable protection against a variety of cancers and infection. This water-soluble vitamin lends itself to the creation and maintenance of neurotransmitters necessary for healthy brain function, proteins, hemoglobin (very important to the red blood cells) and prostaglandins. Vitamin B6 plays an invaluable role in the development of more than sixty enzymes crucial to keeping the body functioning at a peak level. B6 also serves as an important contributor to the metabolism of fats and proteins.

Vitamin B6

B6 not only provides an array of benefits for overall wellness, but its properties lend themselves specifically to healthy sexual functioning. B6 has been shown to increase blood flow. Increased blood flow leads to increased erection time, as well as higher levels of stamina and decreased anxiety.

Many people experience a B6 deficiency, due to issues such as diet, smoking and drinking, but PrematureX provides ample B6 to help men maintain peak sexual functioning along with a higher overall level of wellness.

  • Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shike M, Ross AC, ed. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams and Wilkins, 1999: 413-421.
  • Bender DA. Vitamin B6 requirements and recommendations. Eur J Clin Nutr 1989 ;43:289-309. [PubMed abstract]
  • Gerster H. The importance of vitamin B6 for development of the infant. Human medical and animal experiment studies. Z Ernahrungswiss 1996; 35:309-17. [PubMed abstract]
  • Bender DA. Novel functions of vitamin B6. Proc Nutr Soc 1994; 53:625-30. [PubMed abstract].
  • Chandra R and Sudhakaran L. Regulation of immune responses by Vitamin B6. NY Acad Sci 1990; 585:404-423. [PubMed abstract].
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Folate (as Folic Acid)

  • Quantity: 800 mg
  • % Daily Value/RDI: 200
Folate

Folate performs an important role in spermatogenesis which is an essential factor in male reproduction. Folate is necessary for healthy male fertility and research has linked folate deficiencies to a number of health conditions including depression, glossitis, diarrhea, confusion, and anemia. Alcohol consumption is believed to be at least partially responsible for the depletion of folate.

Folic acid supplements have often been described as a remedy for premature ejaculation, but the properties of folate are intensified when combined with the other active ingredients found in PrematureX.

  • Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP (2007). "The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility". Hum Reprod Update 13 (2): 163–74. doi:10.1093/humupd/dml054. PMID 17099205.
  • Coppen A, Bolander-Gouaille C. (2005). "Treatment of depression: time to consider folic acid and vitamin B12". Journal of Psychopharmacology 19 (1): 59–65. doi:10.1177/0269881105048899. PMID 15671130.
  • Taylor MJ, Carney SM, Goodwin GM, Geddes JR. (2004). "Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials". Journal of Psychopharmacology 18 (2): 251–6. doi:10.1177/0269881104042630. PMID 15260915.
  • Gilbody S, Lightfoot T, Sheldon T (July 2007). "Is low folate a risk factor for depression? A meta‐analysis and exploration of heterogeneity". Journal of Epidemiology and Community Health 61 (7): 631–637. doi:10.1136/jech.2006.050385. PMC 2465760. PMID 17568057.
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Blue Passion Flower Extract 4:1 (Passiflora Coerulea) (leaf)

  • Quantity: 300 mg
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Blue Passion Flower

Blue passion flower is responsible for an array of positive benefits that can promote overall health and well-being. This herbal extract has been used for years to treat conditions including anxiety, insomnia, epilepsy, restlessness and high blood pressure.

While Blue Passion flower has been commonly referred to as a sedative, it is actually more effective in the role of anxiety reduction. This herbal extract calms muscle tension without affecting the respiratory rate of the person taking the herb. Other synthetic chemical sedatives affect the rate of respiration, in contrast to Blue Passion Flower. With no known negative side-effects, Blue Passion Flower doesn’t lead to impotence, unlike other traditional sedatives. Rather than contributing to impotency, the extract of Blue Passion Flower provides the user with a feeling of relaxation and higher levels of testosterone, making it the perfect ingredient to enhance sexual performance.

By reducing the anxiety associated with premature ejaculation, the inclusion of Blue Passion Flower in PrematureX, allows men to focus on the sexual experience, rather than their own fears of inadequacy.

  • J Ethnopharmacol. 2001 Dec;78(2-3):165-70.
  • Anti-anxiety studies on extracts of Passiflora incarnata Linneaus.
  • Dhawan K, Kumar S, Sharma A.
  • Pharmacognosy Division, University Institute of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India.
  • Folic acid and human reproduction-ten important issues for clinicians.
  • Dunlap B, Shelke K, Salem SA, Keith LG.
  • J Exp Clin Assist Reprod. 2011;8:2. Epub 2011 Aug 10.
  • Effect of folic Acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
  • Zhou YH, Tang JY, Wu MJ, Lu J, Wei X, Qin YY, Wang C, Xu JF, He J.
  • PLoS One. 2011;6(9):e25142. Epub 2011 Sep 28.
  • Intra-lateral septal infusions of folic acid alone or combined with various antidepressant drugs produce antidepressant-like actions in male Wistar rats forced to swim.
  • Molina-Hernández M, Téllez-Alcántara NP, Olivera-López JI, Jaramillo MT.
  • Prog Neuropsychopharmacol Biol Psychiatry. 2011 Sep 1. [Epub ahead of print]
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L-Arginine HCL

  • Quantity: 200 mg
  • ---
L-Arginine HCL

L-Arginine is frequently compared to an all-natural form of Viagra, and for good reason. This supplement is an amino acid that is often prescribed to treat erectile dysfunction. L-Arginine is found in its naturally occurring form in meat, fish, nuts and other proteins. It plays a necessary role in the production of insulin and the body’s elimination of ammonia waste. The supplement has also been clinically shown to repair artery damage and deliver valuable benefits to the heart.

L-Arginine is a major player in the formulation of PrematureX not only because of its overall health benefits, but also because of its ability to increase the effects of nitric oxide. Nitric oxide relaxes the blood vessels that are responsible for supplying the penis with blood flow, meaning stronger erections.

  • Arginine Residues are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase.
  • Sundlass NK, Raines RT.
  • Biochemistry. 2011 Oct 7.
  • Dietary L: -arginine supplementation enhances placental growth and reproductive performance in sows.
  • Gao K, Jiang Z, Lin Y, Zheng C, Zhou G, Chen F, Yang L, Wu G.
  • Amino Acids. 2011 Jun 21.
  • Effect of L-Arginine Infusion on Glucose Disposal during Exercise in Humans.
  • Linden KC, Wadley GD, Garnham AP, McConell GK.
  • Med Sci Sports Exerc. 2011 Feb 8
  • Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue.
  • Lorenzen JM, Ückert S, Scheller F, Haller H, Kuczyk MA.
  • World J Urol. 2009 Dec;27(6):805-10.
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Griffonia Seed Extract 4:1

  • Quantity: 200 mg
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Griffonia Seed

Maintaining a positive mental state is one of the biggest factors in a successful, fulfilling sex life. Griffonia seed has been shown in scientific research to increase serotonin levels in the brain, which can lead to a decrease in conditions including anxiety, depression and stress, all of which can sabotage sexual function.

Griffonia seed extract is an all-natural mood booster that allows men to have a stable and healthy mental state, leading to better sexual performance.

  • Arginine Residues are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase.
  • Sundlass NK, Raines RT.
  • Biochemistry. 2011 Oct 7.
  • Dietary L: -arginine supplementation enhances placental growth and reproductive performance in sows.
  • Gao K, Jiang Z, Lin Y, Zheng C, Zhou G, Chen F, Yang L, Wu G.
  • Amino Acids. 2011 Jun 21.
  • Effect of L-Arginine Infusion on Glucose Disposal during Exercise in Humans.
  • Linden KC, Wadley GD, Garnham AP, McConell GK.
  • Med Sci Sports Exerc. 2011 Feb 8
  • Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue.
  • Lorenzen JM, Ückert S, Scheller F, Haller H, Kuczyk MA.
  • World J Urol. 2009 Dec;27(6):805-10.
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Pyrodoxine HCL

  • Quantity: 40 mg
  • ---
Pyrodoxine HCL

Pyrodoxine is a part of the vitamin B6 complex that is vital to the healthy functioning of the nervous system. In addition to providing peak nervous system functioning, this supplement also fights chronic fatigue and depression and promotes the healthy metabolism of fats and proteins.

By including Pyrodoxine in the PrematureX formulation, men can enjoy not only the utmost in nervous system functionality, but the supplement also wards off the symptoms of chronic fatigue and depression, which can contribute to sexual abnormalities and dysfunctions.

Pyrodoxine is pivotal to muscle strength, vitality and overall physical and mental wellness that are required to last longer in bed.

  • Theoretical Study of Pyridoxine (Vitamin B6) Photolysis.
  • Wu M, Xu Q, Strid A, Martell JM, Eriksson LA.
  • J Phys Chem A. 2011 Oct 13. [Epub ahead of print]
  • Lack of efficacy of pyridoxine (vitamin B6) treatment in acquired idiopathic sideroblastic anemia, including refractory anemia with ring sideroblasts.
  • Baumann Kreuziger LM, Wolanskyj AP, Hanson CA, Steensma DP.
  • Eur J Haematol. 2011 Jun;86(6):512-6. doi: 10.1111/j.1600-0609.2011.01604.x. Epub 2011 Apr 1.
  • Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.
  • Footitt EJ, Heales SJ, Mills PB, Allen GF, Oppenheim M, Clayton PT.
  • J Inherit Metab Dis. 2011 Apr;34(2):529-38. Epub 2011 Feb 9.
  • New synthetic route to N-tocopherol derivatives: synthesis of pyrrolopyridinol analogue of α-tocopherol from pyridoxine.
  • Nam TG, Ku JM, Park HG, Porter NA, Jeong BS.
  • Org Biomol Chem. 2011 Mar 21;9(6):1749-55. Epub 2011 Jan 21.
  • Pyridoxine improves platelet nitric oxide synthase dysfunction induced by advanced glycation end products in vitro.
  • Han Y, Liu Y, Mi Q, Xie L, Huang Y, Jiang Q, Chen Q, Ferro A, Liu N, Ji Y.
  • Int J Vitam Nutr Res. 2010 Jun;80(3):168-77.
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Chrysin

  • Quantity: 10 mg
  • ---
Crysin

Chrysin is a naturally occurring compound found in a variety of plants and even honey. When extracted, Chrysin plays an essential role in the production of testosterone. Relied upon by body builders and fitness professionals, Chrysin is an enzyme that is responsible for the synthesis of estrogens that are crucial to sexual development.

Chrysin is not only believed to increase testosterone levels, but also to stimulate semen production, which leads to stronger erections and more intense orgasms.

  • New synthetic anti-inflammatory chrysin analog, 5,7-dihydroxy-8-(pyridine-4yl)flavone.
  • Lim H, Jin JH, Park H, Kim HP.
  • Eur J Pharmacol. 2011 Sep 21. [Epub ahead of print]
  • Investigations on Membrane Perturbation by Chrysin and Its Copper Complex Using Self-Assembled Lipid Bilayers.
  • Selvaraj S, Krishnaswamy S, Devashya V, Sethuraman S, Krishnan UM.
  • Langmuir. 2011 Oct 4. [Epub ahead of print]
  • Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage.
  • Wu NL, Fang JY, Chen M, Wu CJ, Huang CC, Hung CF.
  • J Agric Food Chem. 2011 Aug 10;59(15):8391-400. Epub 2011 Jul 6.
  • Beneficial effects of chrysin on the reproductive system of adult male rats.
  • Ciftci O, Ozdemir I, Aydin M, Beytur A.
  • Andrologia. 2011 Mar 7. doi: 10.1111/j.1439-0272.2010.01127.x. [Epub ahead of print]
  • Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.
  • Zou XQ, Peng SM, Hu CP, Tan LF, Yuan Q, Deng HW, Li YJ.
  • Bioorg Med Chem. 2010 May 1;18(9):3020-5. Epub 2010 Mar 27.
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Other ingredients

Rice flour, Gelatin, Magnesium Stearate, Silicone, Dioxide, Water.

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